InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hey1

Summary

InnateDB Gene

IDBG-130734.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hey1

Gene Name

hairy/enhancer-of-split related with YRPW motif 1

Synonyms

AI316788; AI414254; bHLHb31; CHF2; Herp2; hesr-1; Hesr1; HRT1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040289

Encoded Proteins

IDBP-130736

hairy/enhancer-of-split related with YRPW motif 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164683:
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:8663362-8667039

Strand

Reverse strand

Band

Transcripts

ENSMUST00000042412

ENSMUSP00000038014

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000988	protein binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0035939	microsatellite binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0002076	osteoblast development
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0009948	anterior/posterior axis specification
GO:0010629	negative regulation of gene expression
GO:0045669	positive regulation of osteoblast differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060840	artery development
GO:0071385	cellular response to glucocorticoid stimulus
GO:2000678	negative regulation of transcription regulatory region DNA binding
GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation