InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hey1

Summary

InnateDB Protein

IDBP-130736.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hey1

Protein Name

hairy/enhancer-of-split related with YRPW motif 1

Synonyms

AI316788; AI414254; bHLHb31; CHF2; Herp2; hesr-1; Hesr1; HRT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038014

InnateDB Gene

IDBG-130734 (Hey1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000988	protein binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0035939	microsatellite binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0002076	osteoblast development
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0009948	anterior/posterior axis specification
GO:0010629	negative regulation of gene expression
GO:0045669	positive regulation of osteoblast differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060840	artery development
GO:0071385	cellular response to glucocorticoid stimulus
GO:2000678	negative regulation of transcription regulatory region DNA binding
GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation