Version 5.4
Homo sapiens Gene: SEPT12
Summary
InnateDB Gene IDBG-13096.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPT12
Gene Name septin 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140623
Encoded Proteins
IDBP-13098
septin 12
IDBP-236968
septin 12
IDBP-749357
IDBP-749502
IDBP-751773
IDBP-750428
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:4777669-4788521
Strand Reverse strand
Band p13.3
Transcripts
ENST00000268231 ENSP00000268231
ENST00000396693 ENSP00000379922
ENST00000587603 ENSP00000467237
ENST00000590303
ENST00000588241 ENSP00000464775
ENST00000591624 ENSP00000467281
ENST00000590741 ENSP00000468601
ENST00000591861
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0035091 phosphatidylinositol binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0051301 cell division
Cellular Component
GO:0001725 stress fiber
GO:0005819 spindle
GO:0015630 microtubule cytoskeleton
GO:0016021 integral component of membrane
GO:0030496 midbody
GO:0031105 septin complex
GO:0032154 cleavage furrow
GO:0048471 perinuclear region of cytoplasm
GO:0097227 sperm annulus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022542
View Gene Order
ENSBTAG00000016330
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.126780
RefSeq NM_001154458 NM_144605 XM_006720846
HUGO
OMIM
CCDS CCDS10522 CCDS53987
HPRD 08061
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca