InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEPT12

Summary

InnateDB Protein

IDBP-13098.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEPT12

Protein Name

septin 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000268231

InnateDB Gene

IDBG-13096 (SEPT12)

Protein Structure

UniProt Annotation

Function

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). {ECO:0000250, ECO:0000305}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cell projection, cilium, flagellum. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Found in the sperm annulus.

Disease Associations

Spermatogenic failure 10 (SPGF10) [MIM:614822]: An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. The most prominent feature is a defective sperm annulus, a ring structure that demarcates the midpiece and the principal piece of the sperm tail. {ECO:0000269PubMed:22275165}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:15915442}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0035091	phosphatidylinositol binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007049	cell cycle
GO:0051301	cell division

Cellular Component

GO:0001725	stress fiber
GO:0005819	spindle
GO:0015630	microtubule cytoskeleton
GO:0030496	midbody
GO:0031105	septin complex
GO:0032154	cleavage furrow
GO:0048471	perinuclear region of cytoplasm
GO:0097227	sperm annulus