Version 5.4
Homo sapiens Gene: POU6F2
Summary
InnateDB Gene IDBG-13142.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POU6F2
Gene Name POU class 6 homeobox 2
Synonyms RPF-1; WT5; WTSL
Species Homo sapiens
Ensembl Gene ENSG00000106536
Encoded Proteins
IDBP-294192
POU class 6 homeobox 2
IDBP-372777
POU class 6 homeobox 2
IDBP-372778
POU class 6 homeobox 2
IDBP-478354
POU class 6 homeobox 2
IDBP-593724
POU class 6 homeobox 2
IDBP-600610
POU class 6 homeobox 2
IDBP-588509
POU class 6 homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:38977998-39493095
Strand Forward strand
Band p14.1
Transcripts
ENST00000403058 ENSP00000384004
ENST00000451021 ENSP00000409684
ENST00000416452 ENSP00000404868
ENST00000426456
ENST00000518318 ENSP00000430514
ENST00000517348
ENST00000524147 ENSP00000452911
ENST00000520104 ENSP00000453020
ENST00000464276
ENST00000559001 ENSP00000452633
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007402 ganglion mother cell fate determination
GO:0007417 central nervous system development
GO:0007601 visual perception
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000009734
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.137106 Hs.606612 Hs.633354
RefSeq NM_001166018 NM_007252
HUGO
OMIM
CCDS CCDS34620 CCDS55103
HPRD 10162
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca