InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POU6F2

Summary

InnateDB Protein

IDBP-294192.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU6F2

Protein Name

POU class 6 homeobox 2

Synonyms

RPF-1; WT5; WTSL;

Species

Homo sapiens

Ensembl Protein

ENSP00000384004

InnateDB Gene

IDBG-13142 (POU6F2)

Protein Structure

UniProt Annotation

Function

Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Hereditary susceptibility to Wilms tumor 5 (WT5) [MIM:601583]: Pediatric malignancy of kidney and one of the most common solid cancers in childhood. {ECO:0000269PubMed:11284034}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed only within the CNS, where its expression is restricted to the medical habenulla, to a dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in the retina. {ECO:0000269PubMed:8601806}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007402	ganglion mother cell fate determination
GO:0007417	central nervous system development
GO:0007601	visual perception