InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdk6

Summary

InnateDB Gene

IDBG-131439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk6

Gene Name

cyclin-dependent kinase 6

Synonyms

5830411I20; AI504062; Crk2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040274

Encoded Proteins

IDBP-131441

cyclin-dependent kinase 6

IDBP-621018

cyclin-dependent kinase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21628465

Cdk6 expression is induced upon LPS stimulation via Tlr4-signalling pathway. Cdk6 mediates the increased adhesion of macrophages in response to LPS challenge, and is important for LPS lethality.

InnateDB Annotation from Orthologs

Summary

PMID 21628465

[Homo sapiens] CDK6 expression is induced upon LPS stimulation via TLR4-signalling pathway. CDK6 mediates the increased adhesion of macrophages in response to LPS challenge, and is important for LPS lethality. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105810:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:3343893-3523218

Strand

Forward strand

Band

Transcripts

ENSMUST00000042410	ENSMUSP00000037925
ENSMUST00000165117	ENSMUSP00000126024

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	19 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	95 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030332	cyclin binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007219	Notch signaling pathway
GO:0010628	positive regulation of gene expression
GO:0030097	hemopoiesis
GO:0033077	T cell differentiation in thymus
GO:0042127	regulation of cell proliferation
GO:0043697	cell dedifferentiation
GO:0045087	innate immune response (InnateDB)
GO:0051301	cell division
GO:0060218	hematopoietic stem cell differentiation