InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDK6

Summary

InnateDB Gene

IDBG-26773.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK6

Gene Name

cyclin-dependent kinase 6

Synonyms

PLSTIRE

Species

Homo sapiens

Ensembl Gene

ENSG00000105810

Encoded Proteins

IDBP-26775

cyclin-dependent kinase 6

IDBP-381850

cyclin-dependent kinase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21628465

CDK6 expression is induced upon LPS stimulation via TLR4-signalling pathway. CDK6 mediates the increased adhesion of macrophages in response to LPS challenge, and is important for LPS lethality. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21628465

[Mus musculus] Cdk6 expression is induced upon LPS stimulation via Tlr4-signalling pathway. Cdk6 mediates the increased adhesion of macrophages in response to LPS challenge, and is important for LPS lethality.

Entrez Gene

Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:92604921-92836594

Strand

Reverse strand

Band

q21.2

Transcripts

ENST00000265734	ENSP00000265734
ENST00000424848	ENSP00000397087
ENST00000467166
ENST00000473078
ENST00000491250

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	135 [view]
Protein-Protein	127 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030332	cyclin binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001954	positive regulation of cell-matrix adhesion
GO:0003323	type B pancreatic cell development
GO:0006468	protein phosphorylation
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0009615	response to virus
GO:0010468	regulation of gene expression
GO:0014002	astrocyte development
GO:0021542	dentate gyrus development
GO:0021670	lateral ventricle development
GO:0042063	gliogenesis
GO:0043697	cell dedifferentiation
GO:0045087	innate immune response (InnateDB)
GO:0045596	negative regulation of cell differentiation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045646	regulation of erythrocyte differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045786	negative regulation of cell cycle
GO:0048146	positive regulation of fibroblast proliferation
GO:0048699	generation of neurons
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051301	cell division
GO:2000145	regulation of cell motility
GO:2000773	negative regulation of cellular senescence