InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gria4

Summary

InnateDB Gene

IDBG-131447.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gria4

Gene Name

glutamate receptor, ionotropic, AMPA4 (alpha 4)

Synonyms

GluA4; Glur-4; GluR-D; Glur4; Gluralpha4; spkw1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025892

Encoded Proteins

IDBP-131449

glutamate receptor, ionotropic, AMPA4 (alpha 4)

IDBP-131451

glutamate receptor, ionotropic, AMPA4 (alpha 4)

IDBP-620034

glutamate receptor, ionotropic, AMPA4 (alpha 4)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:4417899-4796234

Strand

Reverse strand

Band

Transcripts

ENSMUST00000063508	ENSMUSP00000066980
ENSMUST00000027020	ENSMUSP00000027020
ENSMUST00000163309	ENSMUSP00000129316

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004971	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic

Cellular Component

GO:0016020	membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0032983	kainate selective glutamate receptor complex
GO:0045202	synapse
GO:0045211	postsynaptic membrane