Homo sapiens Gene: GRIA4 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-69728.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | GRIA4 | ||||||||||||||||||
Gene Name | glutamate receptor, ionotropic, AMPA 4 | ||||||||||||||||||
Synonyms | GluA4; GLUR4; GLUR4C; GLURD | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000152578 | ||||||||||||||||||
Encoded Proteins |
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotrophic, AMPA 4
glutamate receptor, ionotrophic, AMPA 4
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008] Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 11:105609994-105982092 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q22.3 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Unblocking of NMDA receptor, glutamate binding and activation pathway
Trafficking of GluR2-containing AMPA receptors pathway
Trafficking of AMPA receptors pathway
Activation of AMPA receptors pathway
Neuronal System pathway
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
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KEGG |
Neuroactive ligand-receptor interaction pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.503743 Hs.732276 Hs.733043 | ||||||||||||||||||
RefSeq | NM_000829 NM_001077243 NM_001077244 NM_001112812 XM_005271518 XM_006718823 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS41706 CCDS41707 CCDS8333 | ||||||||||||||||||
HPRD | 00694 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||