Version 5.4
Homo sapiens Gene: GRIA4
Summary
InnateDB Gene IDBG-69728.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIA4
Gene Name glutamate receptor, ionotropic, AMPA 4
Synonyms GluA4; GLUR4; GLUR4C; GLURD
Species Homo sapiens
Ensembl Gene ENSG00000152578
Encoded Proteins
IDBP-69730
glutamate receptor, ionotrophic, AMPA 4
IDBP-244237
glutamate receptor, ionotrophic, AMPA 4
IDBP-244239
glutamate receptor, ionotrophic, AMPA 4
IDBP-382710
glutamate receptor, ionotrophic, AMPA 4
IDBP-589143
glutamate receptor, ionotrophic, AMPA 4
IDBP-586553
glutamate receptor, ionotrophic, AMPA 4
IDBP-597389
glutamate receptor, ionotrophic, AMPA 4
IDBP-595156
glutamate receptor, ionotrophic, AMPA 4
IDBP-583502
glutamate receptor, ionotrophic, AMPA 4
IDBP-596294
glutamate receptor, ionotrophic, AMPA 4
IDBP-590237
glutamate receptor, ionotrophic, AMPA 4
IDBP-602112
glutamate receptor, ionotrophic, AMPA 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:105609994-105982092
Strand Forward strand
Band q22.3
Transcripts
ENST00000282499 ENSP00000282499
ENST00000393127 ENSP00000376835
ENST00000393125 ENSP00000376833
ENST00000428631 ENSP00000415551
ENST00000527177 ENSP00000436449
ENST00000531986 ENSP00000436143
ENST00000527669 ENSP00000432371
ENST00000525921 ENSP00000433621
ENST00000525032
ENST00000531011 ENSP00000432443
ENST00000525187 ENSP00000432180
ENST00000530497 ENSP00000435775
ENST00000527687
ENST00000525942 ENSP00000433873
ENST00000533094
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0007215 glutamate receptor signaling pathway
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0030666 endocytic vesicle membrane
GO:0032281 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000025892
View Gene Order
Pathways
NETPATH
REACTOME
REACT_20594
Unblocking of NMDA receptor, glutamate binding and activation pathway
REACT_18422
Trafficking of GluR2-containing AMPA receptors pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_18338
Activation of AMPA receptors pathway
REACT_13685
Neuronal System pathway
REACT_20563
Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.503743 Hs.732276 Hs.733043
RefSeq NM_000829 NM_001077243 NM_001077244 NM_001112812 XM_005271518 XM_006718823
HUGO
OMIM
CCDS CCDS41706 CCDS41707 CCDS8333
HPRD 00694
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca