Version 5.4
Homo sapiens Gene: MED16
Summary
InnateDB Gene IDBG-13168.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED16
Gene Name mediator complex subunit 16
Synonyms DRIP92; THRAP5; TRAP95
Species Homo sapiens
Ensembl Gene ENSG00000175221
Encoded Proteins
IDBP-13170
mediator complex subunit 16
IDBP-13172
mediator complex subunit 16
IDBP-13174
mediator complex subunit 16
IDBP-238762
mediator complex subunit 16
IDBP-763000
IDBP-761896
IDBP-765930
IDBP-759966
IDBP-763830
IDBP-806526
mediator complex subunit 16
IDBP-806527
mediator complex subunit 16
IDBP-806528
mediator complex subunit 16
IDBP-806532
mediator complex subunit 16
IDBP-806540
mediator complex subunit 16
IDBP-806542
mediator complex subunit 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:867630-893218
Strand Reverse strand
Band p13.3
Transcripts
ENST00000312090 ENSP00000308528
ENST00000325464 ENSP00000325612
ENST00000269814 ENSP00000269814
ENST00000395808 ENSP00000379153
ENST00000586342 ENSP00000465827
ENST00000586017 ENSP00000465762
ENST00000592943 ENSP00000466868
ENST00000589119 ENSP00000464810
ENST00000592373 ENSP00000465823
ENST00000621073 ENSP00000478286
ENST00000607471 ENSP00000475725
ENST00000606248 ENSP00000475528
ENST00000606828 ENSP00000480766
ENST00000617672 ENSP00000483533
ENST00000616387 ENSP00000479411
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 66 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0003824 catalytic activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030375 thyroid hormone receptor coactivator activity
GO:0042809 vitamin D receptor binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0008152 metabolic process
GO:0010467 gene expression
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:2000273 positive regulation of receptor activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013833
View Gene Order
ENSBTAG00000047217
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B9TX21
UniProt Splice Variant
Entrez Gene 10025
UniGene
RefSeq NM_005481 XM_006722600
HUGO HGNC:17556
OMIM 604062
CCDS CCDS12047
HPRD
IMGT
EMBL EU392474
GenPept ACB88907
RNA Seq Atlas 10025

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca