Version 5.4
Mus musculus Gene: E2f5
Summary
InnateDB Gene IDBG-131834.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2f5
Gene Name E2F transcription factor 5
Synonyms AU024671; E2F-5
Species Mus musculus
Ensembl Gene ENSMUSG00000027552
Encoded Proteins
IDBP-131836
E2F transcription factor 5
IDBP-627317
E2F transcription factor 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133740:
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:14578671-14606308
Strand Forward strand
Band A1
Transcripts
ENSMUST00000029069 ENSMUSP00000029069
ENSMUST00000165922 ENSMUSP00000127877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009887 organ morphogenesis
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000133740
View Gene Order
ENSBTAG00000009378
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_260005
G1 Phase pathway
REACT_189085
Disease pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_199110
G0 and Early G1 pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_188804
Cell Cycle pathway
REACT_258573
Cyclin D associated events in G1 pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_233572
Gene Expression pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_212101
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
REACT_203903
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
KEGG
mmu04350
TGF-beta signaling pathway pathway
mmu04110
Cell cycle pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_111214
G0 and Early G1 pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_1590
G1 Phase pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
hsa04110
Cell cycle pathway
INOH
PID NCI
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt Q61502
TrEMBL E9Q011
UniProt Splice Variant
Entrez Gene 13559
UniGene
RefSeq NM_007892
OMIM
CCDS CCDS38391
HPRD
IMGT
MGI ID MGI:105091
MGI Symbol E2f5
EMBL AC140350 AK156760 BC003220 X86925
GenPept AAH03220 BAE33842 CAA60508
RNA Seq Atlas 13559

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca