InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: E2F5

Summary

InnateDB Gene

IDBG-27065.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2F5

Gene Name

E2F transcription factor 5, p130-binding

Synonyms

E2F-5

Species

Homo sapiens

Ensembl Gene

ENSG00000133740

Encoded Proteins

IDBP-27067

E2F transcription factor 5, p130-binding

IDBP-373007

E2F transcription factor 5, p130-binding

IDBP-373009

E2F transcription factor 5, p130-binding

IDBP-475388

E2F transcription factor 5, p130-binding

IDBP-481030

E2F transcription factor 5, p130-binding

IDBP-484352

E2F transcription factor 5, p130-binding

IDBP-475766

E2F transcription factor 5, p130-binding

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:85177225-85217158

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000256117	ENSP00000256117
ENST00000418930	ENSP00000414312
ENST00000416274	ENSP00000398124
ENST00000517476	ENSP00000429120
ENST00000521429	ENSP00000428606
ENST00000521234
ENST00000518234	ENSP00000429669
ENST00000520225	ENSP00000430461

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	11 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0009887	organ morphogenesis
GO:0010467	gene expression
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051726	regulation of cell cycle