InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bcor

Summary

InnateDB Gene

IDBG-131964.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcor

Gene Name

BCL6 interacting corepressor

Synonyms

5830466J11Rik; 8430401K06Rik; BcorR; D930024N20Rik; mKIAA1575

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040363

Encoded Proteins

IDBP-131966

BCL6 interacting corepressor

IDBP-131968

BCL6 interacting corepressor

IDBP-249453

BCL6 interacting corepressor

IDBP-249455

BCL6 interacting corepressor

IDBP-533679

BCL6 interacting corepressor

IDBP-540107

BCL6 interacting corepressor

IDBP-539094

BCL6 interacting corepressor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183337:
The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:12036740-12160355

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000065143	ENSMUSP00000068618
ENSMUST00000043441	ENSMUSP00000048024
ENSMUST00000115513	ENSMUSP00000111175
ENSMUST00000115512	ENSMUSP00000111174
ENSMUST00000124033	ENSMUSP00000116258
ENSMUST00000145872	ENSMUSP00000122829
ENSMUST00000123004	ENSMUSP00000120046

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0031072	heat shock protein binding
GO:0042826	histone deacetylase binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000415	negative regulation of histone H3-K36 methylation
GO:0006351	transcription, DNA-templated
GO:0007507	heart development
GO:0030502	negative regulation of bone mineralization
GO:0035518	histone H2A monoubiquitination
GO:0042476	odontogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051572	negative regulation of histone H3-K4 methylation
GO:0060021	palate development
GO:0065001	specification of axis polarity
GO:0070171	negative regulation of tooth mineralization

Cellular Component

GO:0005634	nucleus
GO:0031519	PcG protein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000183337

View Gene Order

ENSBTAG00000047339

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

hdac_classii_pathway

Signaling events mediated by HDAC Class II

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.196328 Mm.408666

RefSeq

NM_001168321 NM_029510 NM_175044 NM_175045 NM_175046

OMIM

CCDS

CCDS30021 CCDS30022 CCDS40872 CCDS40873

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas