InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BCOR

Summary

InnateDB Gene

IDBG-56665.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCOR

Gene Name

BCL6 corepressor

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000183337

Encoded Proteins

IDBP-56667

BCL6 corepressor

IDBP-56669

BCL6 corepressor

IDBP-56671

BCL6 corepressor

IDBP-56675

BCL6 corepressor

IDBP-235553

BCL6 corepressor

IDBP-294482

BCL6 corepressor

IDBP-367401

BCL6 corepressor

IDBP-367430

BCL6 corepressor

IDBP-367434

BCL6 corepressor

IDBP-367441

BCL6 corepressor

IDBP-808011

BCL6 corepressor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:40049815-40177329

Strand

Reverse strand

Band

p11.4

Transcripts

ENST00000378463	ENSP00000367724
ENST00000378455	ENSP00000367716
ENST00000342274	ENSP00000345923
ENST00000378444	ENSP00000367705
ENST00000397354	ENSP00000380512
ENST00000406200	ENSP00000384485
ENST00000413905	ENSP00000408006
ENST00000442018	ENSP00000387552
ENST00000427012	ENSP00000403823
ENST00000412952	ENSP00000390273
ENST00000490976
ENST00000615339	ENSP00000483217

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0031072	heat shock protein binding
GO:0042826	histone deacetylase binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000415	negative regulation of histone H3-K36 methylation
GO:0006351	transcription, DNA-templated
GO:0007507	heart development
GO:0030502	negative regulation of bone mineralization
GO:0035518	histone H2A monoubiquitination
GO:0042476	odontogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051572	negative regulation of histone H3-K4 methylation
GO:0060021	palate development
GO:0065001	specification of axis polarity
GO:0070171	negative regulation of tooth mineralization

Cellular Component

GO:0005634	nucleus
GO:0031519	PcG protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040363

View Gene Order

ENSBTAG00000047339

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

hdac_classii_pathway

Signaling events mediated by HDAC Class II

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.186424 Hs.618974

RefSeq

NM_001123383 NM_001123384 NM_001123385 NM_017745 XM_005272616 XM_005272617 XM_005272618 XM_005272620 XM_006724536

HUGO

OMIM

CCDS

CCDS14250 CCDS48092 CCDS48093

HPRD

06458

IMGT

EMBL

GenPept

RNA Seq Atlas