Version 5.4
Homo sapiens Gene: DPYSL2
Summary
InnateDB Gene IDBG-13200.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPYSL2
Gene Name dihydropyrimidinase-like 2
Synonyms CRMP-2; CRMP2; DHPRP2; DRP-2; DRP2; N2A3; ULIP-2; ULIP2
Species Homo sapiens
Ensembl Gene ENSG00000092964
Encoded Proteins
IDBP-13204
dihydropyrimidinase-like 2
IDBP-485391
dihydropyrimidinase-like 2
IDBP-485390
dihydropyrimidinase-like 2
IDBP-475865
dihydropyrimidinase-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer\'s disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:26514275-26658178
Strand Forward strand
Band p21.2
Transcripts
ENST00000311151 ENSP00000309539
ENST00000521913 ENSP00000427985
ENST00000493789 ENSP00000427954
ENST00000523027 ENSP00000431117
ENST00000523690
ENST00000523093
ENST00000521983
ENST00000474808
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004157 dihydropyrimidinase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0019901 protein kinase binding
Biological Process
GO:0001975 response to amphetamine
GO:0006139 nucleobase-containing compound metabolic process
GO:0006208 pyrimidine nucleobase catabolic process
GO:0006897 endocytosis
GO:0007010 cytoskeleton organization
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007420 brain development
GO:0008152 metabolic process
GO:0014049 positive regulation of glutamate secretion
GO:0021510 spinal cord development
GO:0021772 olfactory bulb development
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0045664 regulation of neuron differentiation
GO:0048489 synaptic vesicle transport
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005874 microtubule
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022048
View Gene Order
ENSBTAG00000018373
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_19199
CRMPs in Sema3A signaling pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593187 Hs.743273
RefSeq NM_001197293 NM_001244604 NM_001386
HUGO
OMIM
CCDS CCDS59096 CCDS6051
HPRD 03914
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca