InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dpysl2

Summary

InnateDB Gene

IDBG-175570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpysl2

Gene Name

dihydropyrimidinase-like 2

Synonyms

AI851130; Crmp2; DRP2; Musunc33; TOAD-64; Ulip2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022048

Encoded Proteins

IDBP-175572

dihydropyrimidinase-like 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092964:
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer\'s disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:66802864-66868688

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022629

ENSMUSP00000022629

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0019901	protein kinase binding

Biological Process

GO:0001975	response to amphetamine
GO:0006208	pyrimidine nucleobase catabolic process
GO:0006897	endocytosis
GO:0007010	cytoskeleton organization
GO:0007420	brain development
GO:0014049	positive regulation of glutamate secretion
GO:0021510	spinal cord development
GO:0021772	olfactory bulb development
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0045664	regulation of neuron differentiation
GO:0048489	synaptic vesicle transport

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005874	microtubule
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome