Version 5.4
Mus musculus Gene: Car3
Summary
InnateDB Gene IDBG-132017.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Car3
Gene Name carbonic anhydrase 3
Synonyms BB219044; Ca3; Car-3
Species Mus musculus
Ensembl Gene ENSMUSG00000027559
Encoded Proteins
IDBP-132019
carbonic anhydrase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164879:
Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:14863538-14872351
Strand Forward strand
Band A1
Transcripts
ENSMUST00000029076 ENSMUSP00000029076
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0016151 nickel cation binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0006979 response to oxidative stress
GO:0045471 response to ethanol
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164879
View Gene Order
ENSBTAG00000015214
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_199096
Reversible hydration of carbon dioxide pathway
KEGG
mmu00910
Nitrogen metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121123
Reversible hydration of carbon dioxide pathway
REACT_111217
Metabolism pathway
REACT_210340
Reversible hydration of carbon dioxide pathway
REACT_219139
Metabolism pathway
KEGG
hsa00910
Nitrogen metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_007606
OMIM
CCDS CCDS17250
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca