Version 5.4
Mus musculus Gene: Pcmt1
Summary
InnateDB Gene IDBG-132359.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcmt1
Gene Name protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
Synonyms C79501; PIMT
Species Mus musculus
Ensembl Gene ENSMUSG00000019795
Encoded Proteins
IDBP-539513
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
IDBP-538588
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
IDBP-539269
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
IDBP-532313
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
IDBP-534457
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
IDBP-531826
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
IDBP-536022
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
IDBP-532787
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120265:
This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer\'s disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:7629373-7681136
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000162606 ENSMUSP00000123866
ENSMUST00000161123 ENSMUSP00000124100
ENSMUST00000159917 ENSMUSP00000124932
ENSMUST00000163085 ENSMUSP00000125144
ENSMUST00000161428 ENSMUSP00000123758
ENSMUST00000160250
ENSMUST00000162682 ENSMUSP00000124246
ENSMUST00000159835 ENSMUSP00000123892
ENSMUST00000159977 ENSMUSP00000124135
ENSMUST00000160517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006479 protein methylation
GO:0008152 metabolic process
GO:0046498 S-adenosylhomocysteine metabolic process
GO:0046500 S-adenosylmethionine metabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120265
View Gene Order
ENSBTAG00000010204
Not yet available
Cross-References
SwissProt P23506
TrEMBL E0CYF2 E0CYJ5 E0CYT8 E0CYV0 E9PWE0 F6TXE3 F7D432 Q545L9 Q8BPI6
UniProt Splice Variant
Entrez Gene 18537
UniGene Mm.396655 Mm.401651 Mm.475554
RefSeq NM_008786 XM_006512588 XM_006512593 XM_006512595
OMIM
CCDS CCDS23687
HPRD
IMGT
MGI ID MGI:97502
MGI Symbol Pcmt1
EMBL AC156391 AK006162 AK075632 BC049613 BC058966 CH466562 M60320 M84684 S72473
GenPept AAA74565 AAA92742 AAB31369 AAH49613 AAH58966 BAB24438 BAC35869 EDL03548
RNA Seq Atlas 18537

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca