InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcmt1

Summary

InnateDB Protein

IDBP-539269.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcmt1

Protein Name

protein-L-isoaspartate (D-aspartate) O-methyltransferase 1

Synonyms

C79501; PIMT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124932

InnateDB Gene

IDBG-132359 (Pcmt1)

Protein Structure

UniProt Annotation

Function

Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl- terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0008168	methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0046498	S-adenosylhomocysteine metabolic process
GO:0046500	S-adenosylmethionine metabolic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:97502

InterPro

IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase
IPR004033 UbiE/COQ5 methyltransferase
IPR013216 Methyltransferase type 11
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01135
PF01209
PF08241

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P23506

PhosphoSite