Version 5.4
Mus musculus Gene: Col4a2
Summary
InnateDB Gene IDBG-132421.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Col4a2
Gene Name collagen, type IV, alpha 2
Synonyms Col4a-2
Species Mus musculus
Ensembl Gene ENSMUSG00000031503
Encoded Proteins
IDBP-132423
collagen, type IV, alpha 2
IDBP-539708
collagen, type IV, alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134871:
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:11312805-11449287
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000033899 ENSMUSP00000033899
ENSMUST00000145295 ENSMUSP00000114737
ENSMUST00000146219
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
Biological Process
GO:0001525 angiogenesis
GO:0006351 transcription, DNA-templated
GO:0016525 negative regulation of angiogenesis
GO:0071560 cellular response to transforming growth factor beta stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005587 collagen type IV trimer
GO:0005604 basement membrane
GO:0031012 extracellular matrix
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134871
View Gene Order
ENSBTAG00000025210
Not yet available
Pathways
NETPATH
REACTOME
REACT_199045
Collagen formation pathway
REACT_199046
Assembly of collagen fibrils and other multimeric structures pathway
REACT_236183
NCAM1 interactions pathway
REACT_198984
Collagen biosynthesis and modifying enzymes pathway
REACT_196595
Anchoring fibril formation pathway
REACT_206066
Extracellular matrix organization pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_196581
Scavenging by Class A Receptors pathway
REACT_202342
Laminin interactions pathway
REACT_261444
Axon guidance pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_263353
Signaling by PDGF pathway
REACT_188576
Developmental Biology pathway
REACT_196606
ECM proteoglycans pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
REACT_188257
Signal Transduction pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
mmu04512
ECM-receptor interaction pathway
mmu05222
Small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu05200
Pathways in cancer pathway
mmu05146
Amoebiasis pathway
mmu04974
Protein digestion and absorption pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_16888
Signaling by PDGF pathway
REACT_150268
Anchoring fibril formation pathway
REACT_150180
Assembly of collagen fibrils and other multimeric structures pathway
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_150401
Collagen degradation pathway
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_18266
Axon guidance pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_111102
Signal Transduction pathway
REACT_163699
Scavenging by Class A Receptors pathway
REACT_163906
ECM proteoglycans pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_169262
Laminin interactions pathway
REACT_120729
Collagen formation pathway
KEGG
hsa04512
ECM-receptor interaction pathway
hsa05222
Small cell lung cancer pathway
hsa04510
Focal adhesion pathway
hsa05200
Pathways in cancer pathway
hsa05146
Amoebiasis pathway
hsa04974
Protein digestion and absorption pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.181021
RefSeq NM_009932
OMIM
CCDS CCDS40220
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca