InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Col4a2

Summary

InnateDB Protein

IDBP-132423.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Col4a2

Protein Name

collagen, type IV, alpha 2

Synonyms

Col4a-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033899

InnateDB Gene

IDBG-132421 (Col4a2)

Protein Structure

UniProt Annotation

Function

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. {ECO:0000269PubMed:3597383}.Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas- dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000255PROSITE-ProRule:PRU00736}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0006351	transcription, DNA-templated
GO:0016525	negative regulation of angiogenesis
GO:0071560	cellular response to transforming growth factor beta stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005587	collagen type IV trimer
GO:0005604	basement membrane
GO:0031012	extracellular matrix
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome