Version 5.4
| Mus musculus Gene: Cldn12 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-132670.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Cldn12 | ||||||||
| Gene Name | claudin 12 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000046798 | ||||||||
| Encoded Proteins |
claudin 12
claudin 12
claudin 12
claudin 12
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene, along with several other family members, is expressed in the inner ear. The protein encoded by this gene and another family member, claudin 2, are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. [provided by RefSeq, Oct 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 5:5505015-5514958 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | A1 | ||||||||
| Transcripts | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Tight junction interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
Cell junction organization pathway
Cell-Cell communication pathway
Cell-cell junction organization pathway
Tight junction interactions pathway
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| KEGG | |||||||||
| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9ET43 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 64945 | ||||||||
| UniGene | Mm.40132 | ||||||||
| RefSeq | NM_022890 XM_006503597 NM_001193659 NM_001193660 NM_001193661 XM_006503598 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS19074 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1929288 | ||||||||
| MGI Symbol | Cldn12 | ||||||||
| EMBL | AF247664 AK039672 AK049331 AK132155 AK166110 BC024057 | ||||||||
| GenPept | AAF98801 AAH24057 BAC30414 BAC33687 BAE21001 BAE38577 | ||||||||
| RNA Seq Atlas | 64945 | ||||||||