Version 5.4
Mus musculus Protein: Cldn12
Summary
InnateDB Protein IDBP-249644.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cldn12
Protein Name claudin 12
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000111106
InnateDB Gene IDBG-132670 (Cldn12)
Protein Structure
UniProt Annotation
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. {ECO:0000250}.
Subcellular Localization Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016328 lateral plasma membrane
GO:0071944 cell periphery
Protein Structure and Domains
PDB ID MGI:1929288
InterPro IPR013287 Claudin-12
PFAM
PRINTS PR01872
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ET43
PhosphoSite PhosphoSite-Q9ET43
TrEMBL
UniProt Splice Variant
Entrez Gene 64945
UniGene Mm.40132
RefSeq NP_001180590
MGI ID
MGI Symbol Cldn12
OMIM
CCDS CCDS19074
HPRD
IMGT
EMBL AF247664 AK039672 AK049331 AK132155 AK166110 BC024057
GenPept AAF98801 AAH24057 BAC30414 BAC33687 BAE21001 BAE38577

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca