Version 5.4
| Mus musculus Gene: Tab2 | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-132816.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Tab2 | ||||||||||||||||||||||
| Gene Name | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | ||||||||||||||||||||||
| Synonyms | 1110030N06Rik; A530078N03Rik; Map3k7ip2; mKIAA0733 | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000015755 | ||||||||||||||||||||||
| Encoded Proteins |
TGF-beta activated kinase 1/MAP3K7 binding protein 2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
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| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] MAP3K7IP2 (TAB2) interacts with both MAP3K7 (TAK1) and TRAF6 and promotes their association, thereby triggering subsequent interleukin-1 signalling events.
[Homo sapiens] MAP3K7IP2 (TAB2) and MAP3K7IP2 (TAB3) activate the NF-kappaB pathway through binding to K63-linked polyubiquitin chains.
[Homo sapiens] MAP3K7IP2 binds to K-63 polyubiquitinated TRAF2 and this association is required for activation of downstream IKK and JNK kinases.
[Homo sapiens] MAP3K7IP2 (TAB2) activates MAP3K7 (TAK1) and also plays an essential role in the deactivation of TAK1 by recruiting PP6 through a polyubiquitin chain-dependent mechanism.
[Homo sapiens] MAP3K7IP2 is an adapter linking MAP3K7 (TAK1) and TRAF6 and also functions as a mediator of TAK1 activation in the IL-1 signalling pathway.
[Homo sapiens] MAP3K7IP2 (TAB2) and MAP3K7IP3 (TAB3) function redundantly as mediators of TAK1 activation in IL-1 and TNF signal transduction.
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| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000055208:
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 10:7905653-7956230 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | A1 | ||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Nuclear signaling by ERBB4 pathway
Downstream TCR signaling pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
MyD88 cascade initiated on plasma membrane pathway
Signaling by ERBB4 pathway
FCERI mediated NF-kB activation pathway
Cytokine Signaling in Immune system pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
TRAF6 mediated induction of TAK1 complex pathway
IRAK2 mediated activation of TAK1 complex pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
activated TAK1 mediates p38 MAPK activation pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
NOD1/2 Signaling Pathway pathway
MyD88 dependent cascade initiated on endosome pathway
Adaptive Immune System pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Activated TLR4 signalling pathway
Interleukin-1 signaling pathway
MyD88-independent cascade pathway
Signal Transduction pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
TCR signaling pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Toll-like receptor signaling pathway pathway
MAPK signaling pathway pathway
NOD-like receptor signaling pathway pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
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| INOH |
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
TNFalpha pathway
IL1 pathway
RANKL pathway
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| REACTOME |
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
activated TAK1 mediates p38 MAPK activation pathway
TRAF6 mediated induction of TAK1 complex pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
IRAK2 mediated activation of TAK1 complex pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
NOD1/2 Signaling Pathway pathway
Downstream TCR signaling pathway
Interleukin-1 signaling pathway
Nuclear signaling by ERBB4 pathway
Signaling by ERBB4 pathway
FCERI mediated NF-kB activation pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
TCR signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
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| KEGG |
MAPK signaling pathway pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
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| INOH |
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
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| PID NCI |
ErbB4 signaling events
IL1-mediated signaling events
p38 MAPK signaling pathway
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| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| UniGene | Mm.193041 Mm.385794 Mm.404214 | ||||||||||||||||||||||
| RefSeq | NM_138667 XM_006512835 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS23691 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||