InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tab2

Summary

InnateDB Protein

IDBP-534230.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tab2

Protein Name

TGF-beta activated kinase 1/MAP3K7 binding protein 2

Synonyms

1110030N06Rik; A530078N03Rik; Map3k7ip2; mKIAA0733;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121266

InnateDB Gene

IDBG-132816 (Tab2)

Protein Structure

UniProt Annotation

Function

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187' (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12150997}. Cytoplasm, cytosol {ECO:0000269PubMed:12150997}. Note=Cytoplasmic when activated. Following IL1 stimulation, localized in the to cytosol.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:12150997}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	96 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0070530	K63-linked polyubiquitin binding

Biological Process

GO:0007507	heart development
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045860	positive regulation of protein kinase activity