InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mmp8

Summary

InnateDB Gene

IDBG-132838.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp8

Gene Name

matrix metallopeptidase 8

Synonyms

BB138268

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005800

Encoded Proteins

IDBP-132840

matrix metallopeptidase 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118113:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:7558429-7568486

Strand

Forward strand

Band

Transcripts

ENSMUST00000018765

ENSMUSP00000018765

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0030574	collagen catabolic process

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000118113

View Gene Order

ENSBTAG00000046732

Not yet available

Pathways

NETPATH

REACTOME

REACT_199000

Activation of Matrix Metalloproteinases pathway

REACT_206066

Extracellular matrix organization pathway

REACT_199052

Degradation of the extracellular matrix pathway

REACT_199055

Collagen degradation pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118682

Activation of Matrix Metalloproteinases pathway

REACT_150401

Collagen degradation pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O70138

TrEMBL

UniProt Splice Variant

Entrez Gene

17394

UniGene

Mm.16415 Mm.457215

RefSeq

NM_008611

OMIM

CCDS

CCDS22808

HPRD

IMGT

MGI ID

MGI:1202395

MGI Symbol

Mmp8

EMBL

AK089234 AK137468 AK154937 BC042742 CH466522 U96696 Y13342

GenPept

AAC12707 AAH42742 BAC40805 BAE23365 BAE32938 CAA73786 EDL24937

RNA Seq Atlas

17394