InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mmp8

Summary

InnateDB Protein

IDBP-132840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp8

Protein Name

matrix metallopeptidase 8

Synonyms

BB138268;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018765

InnateDB Gene

IDBG-132838 (Mmp8)

Protein Structure

UniProt Annotation

Function

Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution.

Subcellular Localization

Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules and released during inflammatory conditions.

Disease Associations

Tissue Specificity

Neutrophils. Expressed in uterus. Low levels in kidney and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0030574	collagen catabolic process

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1202395

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References