Version 5.4
Mus musculus Gene: Ltbp3
Summary
InnateDB Gene IDBG-133057.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ltbp3
Gene Name latent transforming growth factor beta binding protein 3
Synonyms Ltbp2; mFLJ00070
Species Mus musculus
Ensembl Gene ENSMUSG00000024940
Encoded Proteins
IDBP-133061
latent transforming growth factor beta binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168056:
The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5740904-5758532
Strand Forward strand
Band A
Transcripts
ENSMUST00000081496 ENSMUSP00000080214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0001501 skeletal system development
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0030502 negative regulation of bone mineralization
GO:0032331 negative regulation of chondrocyte differentiation
GO:0036363 transforming growth factor beta activation
GO:0045780 positive regulation of bone resorption
GO:0046849 bone remodeling
GO:0060349 bone morphogenesis
GO:0060430 lung saccule development
GO:1902462 positive regulation of mesenchymal stem cell proliferation
GO:2000741 positive regulation of mesenchymal stem cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000168056
View Gene Order
ENSBTAG00000006747
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8VQ06 Q9CVK2
UniProt Splice Variant
Entrez Gene 16998
UniGene
RefSeq NM_008520 XM_006531674
OMIM
CCDS CCDS37891
HPRD
IMGT
MGI ID MGI:1101355
MGI Symbol Ltbp3
EMBL AC134563 AK007774
GenPept BAB25247
RNA Seq Atlas 16998

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca