Homo sapiens Gene: CRYL1
Summary
InnateDB Gene IDBG-13317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRYL1
Gene Name crystallin, lambda 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165475
Encoded Proteins
crystallin, lambda 1
crystallin, lambda 1
crystallin, lambda 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:20403667-20525857
Strand Reverse strand
Band q12.11
Transcripts
ENST00000382812 ENSP00000372262
ENST00000298248 ENSP00000298248
ENST00000480748 ENSP00000479908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0050104 L-gulonate 3-dehydrogenase activity
GO:0070403 NAD+ binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Pentose and glucuronate interconversions pathway
INOH
PID NCI
Cross-References
SwissProt Q9Y2S2
TrEMBL A0A024RDM2 V9HWG2
UniProt Splice Variant
Entrez Gene 51084
UniGene
RefSeq NM_015974 XM_005266416
HUGO HGNC:18246
OMIM 609877
CCDS CCDS41871
HPRD
IMGT
EMBL AF077049 AF087898 AF160216 AK024041 AL161715 AL590096 BC008562 BC071810 BC119660 BC119661 CH471075 EU794604
GenPept AAD27782 AAF67017 AAH08562 AAH71810 AAI19661 AAI19662 AAP97197 ACJ13658 BAG51254 CAH71073 CAH71074 CAI14388 CAI14389 EAX08259 EAX08260 EAX08262
RNA Seq Atlas 51084