Version 5.4
Homo sapiens Protein: CRYL1
Summary
InnateDB Protein IDBP-13319.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRYL1
Protein Name crystallin, lambda 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000372262
InnateDB Gene IDBG-13317 (CRYL1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed, with highest levels in liver and kidney. {ECO:0000269PubMed:12527201}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0050104 L-gulonate 3-dehydrogenase activity
GO:0070403 NAD+ binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
PFAM PF00725
PF02737
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2S2
PhosphoSite PhosphoSite-Q9Y2S2
TrEMBL A0A024RDM2
UniProt Splice Variant
Entrez Gene 51084
UniGene
RefSeq
HUGO HGNC:18246
OMIM 609877
CCDS
HPRD 16762
IMGT
EMBL AF077049 AF087898 AF160216 AK024041 AL161715 AL590096 BC008562 BC071810 BC119660 BC119661 CH471075
GenPept AAD27782 AAF67017 AAH08562 AAH71810 AAI19661 AAI19662 AAP97197 BAG51254 CAH71073 CAH71074 CAI14388 CAI14389 EAX08259 EAX08260 EAX08262

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca