Version 5.4
Mus musculus Gene: Dclre1c
Summary
InnateDB Gene IDBG-133199.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dclre1c
Gene Name DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026648
Encoded Proteins
IDBP-133201
DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)
IDBP-133203
DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)
IDBP-133205
DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)
IDBP-250435
DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)
IDBP-540453
DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152457:
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:3424131-3464130
Strand Forward strand
Band A1
Transcripts
ENSMUST00000102988 ENSMUSP00000100053
ENSMUST00000061852 ENSMUSP00000054300
ENSMUST00000100463 ENSMUSP00000098031
ENSMUST00000115066 ENSMUSP00000110718
ENSMUST00000132565
ENSMUST00000146027
ENSMUST00000131433
ENSMUST00000129657 ENSMUSP00000116883
ENSMUST00000152468
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0016787 hydrolase activity
Biological Process
GO:0000723 telomere maintenance
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0010212 response to ionizing radiation
GO:0030183 B cell differentiation
GO:0051276 chromosome organization
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000152457
View Gene Order
ENSBTAG00000010220
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03450
Non-homologous end-joining pathway
mmu05340
Primary immunodeficiency pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03450
Non-homologous end-joining pathway
hsa05340
Primary immunodeficiency pathway
INOH
PID NCI
atm_pathway
ATM pathway
dnapk_pathway
DNA-PK pathway in nonhomologous end joining
Cross-References
SwissProt Q8K4J0
TrEMBL
UniProt Splice Variant
Entrez Gene 227525
UniGene Mm.23483 Mm.442710 Mm.446503 Mm.446697 Mm.447773 Mm.447788
RefSeq XM_006497464 NM_001110214 NM_146114 NM_175683
OMIM
CCDS CCDS15649 CCDS15650 CCDS50486
HPRD
IMGT
MGI ID MGI:2441769
MGI Symbol Dclre1c
EMBL AF387731 AK037126 AK052369 AK088810 AL732620
GenPept AAM89119 BAC29713 BAC34960 BAC40586 CAM16038 CAM16039 CAM16040
RNA Seq Atlas 227525

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca