Version 5.4
Bos taurus Gene: DCLRE1C
Summary
InnateDB Gene IDBG-638047.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCLRE1C
Gene Name protein artemis
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010220
Encoded Proteins
IDBP-690090
protein artemis
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152457:
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:29840395-29874417
Strand Reverse strand
Band
Transcripts
ENSBTAT00000013484 ENSBTAP00000013484
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0016787 hydrolase activity
Biological Process
GO:0000723 telomere maintenance
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0010212 response to ionizing radiation
GO:0030183 B cell differentiation
GO:0051276 chromosome organization
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000152457
View Gene Order
ENSMUSG00000026648
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa03450
Non-homologous end-joining pathway
hsa05340
Primary immunodeficiency pathway
mmu03450
Non-homologous end-joining pathway
mmu05340
Primary immunodeficiency pathway
INOH
PID NCI
atm_pathway
ATM pathway
dnapk_pathway
DNA-PK pathway in nonhomologous end joining
Cross-References
SwissProt
TrEMBL A6QLL4
UniProt Splice Variant
Entrez Gene 517886
UniGene Bt.59419
RefSeq NM_001100377
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148006 DAAA02035537 DAAA02035538
GenPept AAI48007
RNA Seq Atlas 517886

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca