Version 5.4
Mus musculus Gene: Ngly1
Summary
InnateDB Gene IDBG-133214.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ngly1
Gene Name N-glycanase 1
Synonyms 1110002C09Rik; Png1; PNGase
Species Mus musculus
Ensembl Gene ENSMUSG00000021785
Encoded Proteins
IDBP-133216
N-glycanase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151092:
This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:16249280-16311926
Strand Forward strand
Band A2
Transcripts
ENSMUST00000022310 ENSMUSP00000022310
ENSMUST00000153109
ENSMUST00000143947
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006289 nucleotide-excision repair
GO:0006516 glycoprotein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000151092
View Gene Order
ENSBTAG00000003793
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q9JI78
TrEMBL
UniProt Splice Variant
Entrez Gene 59007
UniGene Mm.258381 Mm.446643
RefSeq NM_021504
OMIM
CCDS CCDS26832
HPRD
IMGT
MGI ID MGI:1913276
MGI Symbol Ngly1
EMBL AF250927 AK003279 AK028248 AY225417 BC028961
GenPept AAF74723 AAH28961 AAP03060 BAB22686 BAC25839
RNA Seq Atlas 59007

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca