InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trim27

Summary

InnateDB Gene

IDBG-133351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim27

Gene Name

tripartite motif-containing 27

Synonyms

AW538890; Gm19403; Rfp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021326

Encoded Proteins

IDBP-133353

tripartite motif-containing 27

IDBP-532018

tripartite motif-containing 27

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23438823

[Homo sapiens] TRIM27 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204713:
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:21179445-21194724

Strand

Forward strand

Band

Transcripts

ENSMUST00000021761	ENSMUSP00000021761
ENSMUST00000124052
ENSMUST00000124794
ENSMUST00000139287	ENSMUSP00000115397

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	82 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002820	negative regulation of adaptive immune response
GO:0006351	transcription, DNA-templated
GO:0006469	negative regulation of protein kinase activity
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032897	negative regulation of viral transcription
GO:0034314	Arp2/3 complex-mediated actin nucleation
GO:0042147	retrograde transport, endosome to Golgi
GO:0045087	innate immune response
GO:0045814	negative regulation of gene expression, epigenetic
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070206	protein trimerization
GO:0070534	protein K63-linked ubiquitination
GO:0072643	interferon-gamma secretion
GO:0090281	negative regulation of calcium ion import
GO:1900041	negative regulation of interleukin-2 secretion
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0016605	PML body
GO:0030904	retromer complex
GO:0031965	nuclear membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000204713

View Gene Order

ENSBTAG00000000871

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.314056 Mm.414013 Mm.418471 Mm.490349

RefSeq

NM_009054 XM_006516606

OMIM

CCDS

CCDS36607

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas