InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Utrn

Summary

InnateDB Gene

IDBG-133665.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Utrn

Gene Name

utrophin

Synonyms

AA589569; Dmdl; DRP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019820

Encoded Proteins

IDBP-133667

utrophin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152818:
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:12382188-12861735

Strand

Reverse strand

Band

Transcripts

ENSMUST00000076817

ENSMUSP00000076093

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005178	integrin binding
GO:0005488	binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017166	vinculin binding
GO:0019901	protein kinase binding

Biological Process

GO:0001954	positive regulation of cell-matrix adhesion
GO:0007527	adult somatic muscle development
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016020	membrane
GO:0030175	filopodium
GO:0031527	filopodium membrane
GO:0031594	neuromuscular junction
GO:0043234	protein complex
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome
GO:0070938	contractile ring

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000152818

View Gene Order

ENSBTAG00000009665

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.331784 Mm.402624 Mm.473471

RefSeq

NM_011682 XM_006512706 XM_006512707 XM_006512708 XM_006512709 XM_006512710 XM_006512711 XM_006512713 XM_006512714

OMIM

CCDS

CCDS35841

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas