Version 5.4
Mus musculus Gene: Stk3
Summary
InnateDB Gene IDBG-134139.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stk3
Gene Name serine/threonine kinase 3
Synonyms 0610042I06Rik; mess1; MST; Mst2; Mst3; Ste20
Species Mus musculus
Ensembl Gene ENSMUSG00000022329
Encoded Proteins
IDBP-134141
serine/threonine kinase 3 (Ste20, yeast homolog)
IDBP-134143
serine/threonine kinase 3 (Ste20, yeast homolog)
IDBP-538921
serine/threonine kinase 3 (Ste20, yeast homolog)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104375:
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:34875496-35155806
Strand Reverse strand
Band B3.1
Transcripts
ENSMUST00000018476 ENSMUSP00000018476
ENSMUST00000067033 ENSMUSP00000064225
ENSMUST00000128425
ENSMUST00000138841 ENSMUSP00000116310
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0046983 protein dimerization activity
Biological Process
GO:0001841 neural tube formation
GO:0003157 endocardium development
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007417 central nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0023014 signal transduction by phosphorylation
GO:0035329 hippo signaling
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0046330 positive regulation of JNK cascade
GO:0046621 negative regulation of organ growth
GO:0051897 positive regulation of protein kinase B signaling
GO:0060215 primitive hemopoiesis
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097284 hepatocyte apoptotic process
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104375
View Gene Order
ENSBTAG00000026234
Not yet available
Pathways
NETPATH
REACTOME
REACT_196537
Signaling by Hippo pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.262330 Mm.460842
RefSeq NM_019635 XM_006520120 XM_006520121
OMIM
CCDS CCDS37059
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca