Homo sapiens Gene: MPLKIP
Summary
InnateDB Gene IDBG-13415.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPLKIP
Gene Name M-phase specific PLK1 interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168303
Encoded Proteins
chromosome 7 open reading frame 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:40126023-40134659
Strand Reverse strand
Band p14.1
Transcripts
ENST00000306984 ENSP00000304553
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0030496 midbody
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q8TAP9
TrEMBL A4D1W6
UniProt Splice Variant
Entrez Gene 136647
UniGene Hs.627700
RefSeq NM_138701
HUGO HGNC:16002
OMIM 609188
CCDS CCDS5463
HPRD
IMGT
EMBL AK290098 BC026265 CH236951 CH471073
GenPept AAH26265 BAF82787 EAL23999 EAW94134
RNA Seq Atlas 136647