Version 5.4
Homo sapiens Protein: MPLKIP
Summary
InnateDB Protein IDBP-13417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPLKIP
Protein Name chromosome 7 open reading frame 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000304553
InnateDB Gene IDBG-13415 (MPLKIP)
Protein Structure
UniProt Annotation
Function May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269PubMed:17310276}.
Subcellular Localization Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase.
Disease Associations Trichothiodystrophy non-photosensitive 1 (TTDN1) [MIM:234050]: TTDN1 is an autosomal recessive disease characterized by sulfur-deficient brittle hair, intellectual impairment, decreased male fertility and no cutaneous photosensitivity. {ECO:0000269PubMed:15645389}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle, pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles. {ECO:0000269PubMed:11829489, ECO:0000269PubMed:15645389}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0030496 midbody
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TAP9
PhosphoSite PhosphoSite-Q8TAP9
TrEMBL A4D1W6
UniProt Splice Variant
Entrez Gene 136647
UniGene Hs.627700
RefSeq NP_619646
HUGO HGNC:16002
OMIM 609188
CCDS CCDS5463
HPRD 12907
IMGT
EMBL AK290098 BC026265 CH236951 CH471073
GenPept AAH26265 BAF82787 EAL23999 EAW94134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca