Version 5.4
Mus musculus Gene: F7
Summary
InnateDB Gene IDBG-134155.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F7
Gene Name coagulation factor VII
Synonyms AI132620; Cf7; FVII; mfVII
Species Mus musculus
Ensembl Gene ENSMUSG00000031443
Encoded Proteins
IDBP-134157
coagulation factor VII
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057593:
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:13026034-13035809
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000033820 ENSMUSP00000033820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0003824 catalytic activity
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005102 receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0007623 circadian rhythm
GO:0009725 response to hormone
GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0014070 response to organic cyclic compound
GO:0030194 positive regulation of blood coagulation
GO:0031100 organ regeneration
GO:0031667 response to nutrient levels
GO:0032571 response to vitamin K
GO:0043627 response to estrogen
GO:0050927 positive regulation of positive chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
GO:0060416 response to growth hormone
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031982 vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000057593
View Gene Order
ENSBTAG00000007411
Not yet available
Pathways
NETPATH
REACTOME
REACT_115781
Bmal1:Clock,Npas2 activates circadian gene expression pathway
REACT_24972
Circadian Clock pathway
REACT_200794
Mus musculus biological processes pathway
REACT_224553
Hemostasis pathway
REACT_241925
Circadian Clock pathway
REACT_245393
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_240293
Extrinsic Pathway pathway
REACT_235097
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_235159
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_254191
Gamma-carboxylation of protein precursors pathway
REACT_229541
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_255710
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_198620
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
KEGG
mmu04610
Complement and coagulation cascades pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1573
Extrinsic Pathway pathway
REACT_1050
Gamma-carboxylation of protein precursors pathway
REACT_1906
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_733
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_1132
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_22161
Post-translational protein modification pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_17015
Metabolism of proteins pathway
REACT_604
Hemostasis pathway
REACT_212120
Gamma-carboxylation of protein precursors pathway
REACT_216886
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
REACT_212196
Hemostasis pathway
REACT_216819
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
REACT_213782
Metabolism of proteins pathway
REACT_214405
Post-translational protein modification pathway
REACT_224221
Extrinsic Pathway pathway
REACT_201970
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
REACT_206715
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_210271
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_217138
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_227144
Circadian Clock pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
INOH
PID NCI
Cross-References
SwissProt P70375
TrEMBL Q542C2
UniProt Splice Variant
Entrez Gene 14068
UniGene Mm.4827
RefSeq NM_010172
OMIM
CCDS CCDS22104
HPRD
IMGT
MGI ID MGI:109325
MGI Symbol F7
EMBL AK089402 AK154742 AK171362 BC061149 CH466566 U44795 U66079
GenPept AAC33796 AAC52570 AAH61149 BAC40867 BAE32799 BAE42410 EDL22109
RNA Seq Atlas 14068

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca