Version 5.4
| Bos taurus Gene: F7 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-634312.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | F7 | ||||||||||||||||||
| Gene Name | Coagulation factor VII Factor VII light chain Factor VII heavy chain | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||
| Ensembl Gene | ENSBTAG00000007411 | ||||||||||||||||||
| Encoded Proteins |
Coagulation factor VIIFactor VII light chainFactor VII heavy chain
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057593:
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 12:90508105-90514384 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | |||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Gamma-carboxylation of protein precursors pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Hemostasis pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Extrinsic Pathway pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Circadian Clock pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Extrinsic Pathway pathway
Gamma-carboxylation of protein precursors pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Circadian Clock pathway
Post-translational protein modification pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Metabolism of proteins pathway
Hemostasis pathway
Bmal1:Clock,Npas2 activates circadian gene expression pathway
Circadian Clock pathway
Mus musculus biological processes pathway
Hemostasis pathway
Circadian Clock pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Extrinsic Pathway pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Gamma-carboxylation of protein precursors pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
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| KEGG |
Complement and coagulation cascades pathway
Complement and coagulation cascades pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P22457 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 617960 | ||||||||||||||||||
| UniGene | Bt.37397 | ||||||||||||||||||
| RefSeq | NM_001034806 XM_005213994 XM_005213995 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | |||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | BC146045 BT021584 | ||||||||||||||||||
| GenPept | AAI46046 AAX46431 | ||||||||||||||||||
| RNA Seq Atlas | 617960 | ||||||||||||||||||