InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Camk4

Summary

InnateDB Gene

IDBG-134175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Camk4

Gene Name

calcium/calmodulin-dependent protein kinase IV

Synonyms

A430110E23Rik; AI666733; CaMKIV; CaMKIV/Gr; D18Bwg0362e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038128

Encoded Proteins

IDBP-134177

calcium/calmodulin-dependent protein kinase IV

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000152495:
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:32939041-33195767

Strand

Forward strand

Band

Transcripts

ENSMUST00000042868

ENSMUSP00000046539

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007270	neuron-neuron synaptic transmission
GO:0007616	long-term memory
GO:0043011	myeloid dendritic cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046827	positive regulation of protein export from nucleus

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000152495

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

mmu04020

Calcium signaling pathway pathway

mmu04720

Long-term potentiation pathway

mmu04722

Neurotrophin signaling pathway pathway

mmu04380

Osteoclast differentiation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15502

CaMK IV-mediated phosphorylation of CREB pathway

REACT_9000

Calmodulin induced events pathway

REACT_9053

CaM pathway pathway

REACT_111064

DAG and IP3 signaling pathway

REACT_147814

DAP12 signaling pathway

REACT_147694

DAP12 interactions pathway

REACT_12079

PLC-gamma1 signalling pathway

REACT_12478

EGFR interacts with phospholipase C-gamma pathway

REACT_9417

Signaling by EGFR pathway

REACT_15426

PLC beta mediated events pathway

REACT_15295

Opioid Signalling pathway

REACT_115720

PLCG1 events in ERBB2 signaling pathway

REACT_115755

Signaling by ERBB2 pathway

REACT_21310

Phospholipase C-mediated cascade pathway

REACT_9470

Signaling by FGFR pathway

REACT_17025

Downstream signal transduction pathway

REACT_16888

Signaling by PDGF pathway

REACT_20652

Activation of CaMK IV pathway

REACT_20661

CREB phosphorylation through the activation of CaMKK pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_200751

Organelle biogenesis and maintenance pathway

REACT_11061

Signalling by NGF pathway

REACT_115871

Signaling by EGFR in Cancer pathway

REACT_21272

Downstream signaling of activated FGFR pathway

REACT_13685

Neuronal System pathway

REACT_200788

Mitochondrial biogenesis pathway

REACT_14797

Signaling by GPCR pathway

REACT_6802

Innate Immune System pathway

REACT_111102

Signal Transduction pathway

REACT_20593

Post NMDA receptor activation events pathway

REACT_15526

G-protein mediated events pathway

REACT_6900

Immune System pathway

REACT_20563

Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway

REACT_200608

Transcriptional activation of mitochondrial biogenesis pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_15307

Ca-dependent events pathway

REACT_116125

Disease pathway

KEGG

hsa04720

Long-term potentiation pathway

hsa04020

Calcium signaling pathway pathway

hsa04722

Neurotrophin signaling pathway pathway

hsa04380

Osteoclast differentiation pathway

INOH

PID NCI

pi3kplctrkpathway

Trk receptor signaling mediated by PI3K and PLC-gamma

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

hdac_classii_pathway

Signaling events mediated by HDAC Class II

nfat_3pathway

Role of Calcineurin-dependent NFAT signaling in lymphocytes

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.222329 Mm.422158 Mm.470956

RefSeq

NM_009793 XM_006525543 XM_006525544 XM_006525545 XM_006525546 XM_006525547

OMIM

CCDS

CCDS29122

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas