InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CAMK4

Summary

InnateDB Gene

IDBG-36661.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAMK4

Gene Name

calcium/calmodulin-dependent protein kinase IV

Synonyms

caMK; CaMK IV; CaMK-GR; IV

Species

Homo sapiens

Ensembl Gene

ENSG00000152495

Encoded Proteins

IDBP-36665

calcium/calmodulin-dependent protein kinase IV

IDBP-476967

calcium/calmodulin-dependent protein kinase IV

IDBP-485303

calcium/calmodulin-dependent protein kinase IV

IDBP-473457

calcium/calmodulin-dependent protein kinase IV

IDBP-478420

calcium/calmodulin-dependent protein kinase IV

IDBP-480061

calcium/calmodulin-dependent protein kinase IV

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:111223653-111494886

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000282356	ENSP00000282356
ENST00000508074	ENSP00000426940
ENST00000512453	ENSP00000422634
ENST00000515231	ENSP00000424912
ENST00000504544	ENSP00000423761
ENST00000509408
ENST00000514007	ENSP00000421606
ENST00000504090
ENST00000502916
ENST00000505763
ENST00000509645
ENST00000510858
ENST00000512890

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006913	nucleocytoplasmic transport
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007268	synaptic transmission
GO:0007270	neuron-neuron synaptic transmission
GO:0007616	long-term memory
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0033081	regulation of T cell differentiation in thymus
GO:0043011	myeloid dendritic cell differentiation
GO:0045087	innate immune response
GO:0045670	regulation of osteoclast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046827	positive regulation of protein export from nucleus
GO:0048011	neurotrophin TRK receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000038128

View Gene Order

Pathways

NETPATH

REACTOME

REACT_15502

CaMK IV-mediated phosphorylation of CREB pathway

REACT_9000

Calmodulin induced events pathway

REACT_9053

CaM pathway pathway

REACT_111064

DAG and IP3 signaling pathway

REACT_147814

DAP12 signaling pathway

REACT_147694

DAP12 interactions pathway

REACT_12079

PLC-gamma1 signalling pathway

REACT_12478

EGFR interacts with phospholipase C-gamma pathway

REACT_9417

Signaling by EGFR pathway

REACT_15426

PLC beta mediated events pathway

REACT_15295

Opioid Signalling pathway

REACT_115720

PLCG1 events in ERBB2 signaling pathway

REACT_115755

Signaling by ERBB2 pathway

REACT_21310

Phospholipase C-mediated cascade pathway

REACT_9470

Signaling by FGFR pathway

REACT_17025

Downstream signal transduction pathway

REACT_16888

Signaling by PDGF pathway

REACT_20652

Activation of CaMK IV pathway

REACT_20661

CREB phosphorylation through the activation of CaMKK pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_200751

Organelle biogenesis and maintenance pathway

REACT_11061

Signalling by NGF pathway

REACT_115871

Signaling by EGFR in Cancer pathway

REACT_21272

Downstream signaling of activated FGFR pathway

REACT_13685

Neuronal System pathway

REACT_200788

Mitochondrial biogenesis pathway

REACT_14797

Signaling by GPCR pathway

REACT_6802

Innate Immune System pathway

REACT_111102

Signal Transduction pathway

REACT_20593

Post NMDA receptor activation events pathway

REACT_15526

G-protein mediated events pathway

REACT_6900

Immune System pathway

REACT_20563

Activation of NMDA receptor upon glutamate binding and postsynaptic events pathway

REACT_200608

Transcriptional activation of mitochondrial biogenesis pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_15370

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

REACT_15307

Ca-dependent events pathway

REACT_116125

Disease pathway

KEGG

hsa04720

Long-term potentiation pathway

hsa04020

Calcium signaling pathway pathway

hsa04722

Neurotrophin signaling pathway pathway

hsa04380

Osteoclast differentiation pathway

INOH

PID NCI

pi3kplctrkpathway

Trk receptor signaling mediated by PI3K and PLC-gamma

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

hdac_classii_pathway

Signaling events mediated by HDAC Class II

nfat_3pathway

Role of Calcineurin-dependent NFAT signaling in lymphocytes

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.591269

RefSeq

NM_001744

HUGO

OMIM

CCDS

CCDS4103

HPRD

07169

IMGT

EMBL

GenPept

RNA Seq Atlas