Version 5.4
Mus musculus Gene: Exoc4
Summary
InnateDB Gene IDBG-134233.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Exoc4
Gene Name exocyst complex component 4
Synonyms C78892; Sec8; Sec8l1
Species Mus musculus
Ensembl Gene ENSMUSG00000029763
Encoded Proteins
IDBP-134237
exocyst complex component 4
IDBP-134241
exocyst complex component 4
IDBP-250411
exocyst complex component 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131558:
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33249085-33973979
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000090381 ENSMUSP00000087859
ENSMUST00000052266 ENSMUSP00000051965
ENSMUST00000115080 ENSMUSP00000110732
ENSMUST00000132842
ENSMUST00000137043
ENSMUST00000139132
ENSMUST00000152835
ENSMUST00000156207
ENSMUST00000143190
ENSMUST00000134653
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006904 vesicle docking involved in exocytosis
GO:0015031 protein transport
Cellular Component
GO:0000145 exocyst
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032584 growth cone membrane
GO:0035748 myelin sheath abaxonal region
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131558
View Gene Order
ENSBTAG00000014112
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_247926
Metabolism of proteins pathway
REACT_206913
Peptide hormone metabolism pathway
REACT_207837
Insulin processing pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
KEGG
mmu04530
Tight junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15550
Insulin processing pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
arf6_traffickingpathway
Arf6 trafficking events
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.265512 Mm.407846 Mm.461712 Mm.490746
RefSeq NM_009148
OMIM
CCDS CCDS19987
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca