Version 5.4
Homo sapiens Gene: EXOC4
Summary
InnateDB Gene IDBG-41988.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EXOC4
Gene Name exocyst complex component 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131558
Encoded Proteins
IDBP-41990
exocyst complex component 4
IDBP-244181
exocyst complex component 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:133253073-134066589
Strand Forward strand
Band q33
Transcripts
ENST00000253861 ENSP00000253861
ENST00000393161 ENSP00000376868
ENST00000486013
ENST00000462055
ENST00000481074
ENST00000492326
ENST00000480840
ENST00000486409
ENST00000479839
ENST00000494685
ENST00000498024
ENST00000483800
ENST00000469115
ENST00000489931
ENST00000482089
ENST00000460346
ENST00000463150
ENST00000472020
ENST00000478265
ENST00000484397
ENST00000480337
ENST00000459626
ENST00000466000
ENST00000468932
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 47 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006904 vesicle docking involved in exocytosis
GO:0015031 protein transport
GO:0044267 cellular protein metabolic process
GO:0061024 membrane organization
Cellular Component
GO:0000145 exocyst
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032584 growth cone membrane
GO:0035748 myelin sheath abaxonal region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029763
View Gene Order
ENSBTAG00000014112
Not yet available
Pathways
NETPATH
REACTOME
REACT_15550
Insulin processing pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
arf6_traffickingpathway
Arf6 trafficking events
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.321273 Hs.691378
RefSeq NM_001037126 NM_021807 XM_005250523
HUGO
OMIM
CCDS CCDS43648 CCDS5829
HPRD 12185
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca