Version 5.4
Mus musculus Gene: Sec61a2
Summary
InnateDB Gene IDBG-134544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sec61a2
Gene Name Sec61, alpha subunit 2 (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025816
Encoded Proteins
IDBP-134546
Sec61, alpha subunit 2 (S. cerevisiae)
IDBP-134548
Sec61, alpha subunit 2 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065665:
The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:5870987-5895432
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000102981 ENSMUSP00000100046
ENSMUST00000026926 ENSMUSP00000026926
ENSMUST00000132908
ENSMUST00000124859
ENSMUST00000153240
ENSMUST00000124985
ENSMUST00000132469
ENSMUST00000148745
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0043022 ribosome binding
Biological Process
GO:0015031 protein transport
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000065665
View Gene Order
ENSBTAG00000019508
Not yet available
Pathways
NETPATH
REACTOME
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_254308
Translation pathway
REACT_230745
Immune System pathway
REACT_247926
Metabolism of proteins pathway
REACT_199105
ER-Phagosome pathway pathway
REACT_196445
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_199113
Antigen processing-Cross presentation pathway
REACT_233572
Gene Expression pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu03060
Protein export pathway
mmu04145
Phagosome pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111178
ER-Phagosome pathway pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_1014
Translation pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_71
Gene Expression pathway
REACT_211738
ER-Phagosome pathway pathway
REACT_221721
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_212672
Class I MHC mediated antigen processing & presentation pathway
REACT_226022
Gene Expression pathway
REACT_213138
Immune System pathway
REACT_209048
Translation pathway
REACT_213782
Metabolism of proteins pathway
REACT_214469
Adaptive Immune System pathway
REACT_218645
Antigen processing-Cross presentation pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa03060
Protein export pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9JLR1
TrEMBL
UniProt Splice Variant
Entrez Gene 57743
UniGene Mm.21435 Mm.469017
RefSeq NM_021305
OMIM
CCDS CCDS15668
HPRD
IMGT
MGI ID MGI:1931071
MGI Symbol Sec61a2
EMBL AF145254 AF222748 AK077701 BC005458
GenPept AAF66696 AAG44253 AAH05458 BAC36967
RNA Seq Atlas 57743

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca