Version 5.4
| Mus musculus Protein: Sec61a2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-134546.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Sec61a2 | ||||||||
| Protein Name | Sec61, alpha subunit 2 (S. cerevisiae) | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000100046 | ||||||||
| InnateDB Gene | IDBG-134544 (Sec61a2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1931071 | ||||||||
| InterPro |
IPR002208
SecY/SEC61-alpha family IPR019561 Translocon Sec61/SecY, plug domain IPR023201 SecY subunit domain |
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| PFAM |
PF00344
PF10559 |
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| PRINTS | |||||||||
| PIRSF |
PIRSF004557
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| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9JLR1 | ||||||||
| PhosphoSite | PhosphoSite-Q9JLR1 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 57743 | ||||||||
| UniGene | Mm.469017 | ||||||||
| RefSeq | NP_067280 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Sec61a2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS15668 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF145254 AF222748 AK077701 BC005458 | ||||||||
| GenPept | AAF66696 AAG44253 AAH05458 BAC36967 | ||||||||