Version 5.4
Mus musculus Gene: Ppp2r5b
Summary
InnateDB Gene IDBG-134800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp2r5b
Gene Name protein phosphatase 2, regulatory subunit B (B56), beta isoform
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000024777
Encoded Proteins
IDBP-134802
protein phosphatase 2, regulatory subunit B (B56), beta isoform
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068971:
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:6227765-6235872
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025695 ENSMUSP00000025695
ENSMUST00000153155
ENSMUST00000148693
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0010469 regulation of receptor activity
GO:0010976 positive regulation of neuron projection development
GO:0031334 positive regulation of protein complex assembly
GO:0031952 regulation of protein autophosphorylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050790 regulation of catalytic activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051388 positive regulation of nerve growth factor receptor signaling pathway
GO:0070317 negative regulation of G0 to G1 transition
GO:0071158 positive regulation of cell cycle arrest
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0000159 protein phosphatase type 2A complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000068971
View Gene Order
ENSBTAG00000007061
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04114
Oocyte meiosis pathway
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_19405
CTLA4 inhibitory signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_23879
Platelet sensitization by LDL pathway
REACT_23876
Platelet homeostasis pathway
REACT_11065
Beta-catenin phosphorylation cascade pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_115566
Cell Cycle pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04114
Oocyte meiosis pathway
hsa03015
mRNA surveillance pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL Q6PD28
UniProt Splice Variant
Entrez Gene 225849
UniGene Mm.118076 Mm.488465
RefSeq NM_198168
OMIM
CCDS CCDS29499
HPRD
IMGT
MGI ID MGI:2388480
MGI Symbol Ppp2r5b
EMBL AC127556 AK171041 AK171178 BC058977 CH466612
GenPept AAH58977 BAE42206 BAE42296 EDL33229
RNA Seq Atlas 225849

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca