Version 5.4
| Bos taurus Gene: PPP2R5B | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-644096.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | PPP2R5B | ||||||||
| Gene Name | serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000007061 | ||||||||
| Encoded Proteins |
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068971:
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 29:43765388-43774236 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Resolution of Sister Chromatid Cohesion pathway
Mitotic Prometaphase pathway
Separation of Sister Chromatids pathway
CTLA4 inhibitory signaling pathway
Costimulation by the CD28 family pathway
Platelet sensitization by LDL pathway
Platelet homeostasis pathway
Beta-catenin phosphorylation cascade pathway
Degradation of beta-catenin by the destruction complex pathway
XBP1(S) activates chaperone genes pathway
IRE1alpha activates chaperones pathway
truncated APC mutants destabilize the destruction complex pathway
Unfolded Protein Response (UPR) pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
APC truncation mutants have impaired AXIN binding pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Signal Transduction pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Cell Cycle pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
Immune System pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
M Phase pathway
Mitotic Anaphase pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
Hemostasis pathway
Mitotic Metaphase and Anaphase pathway
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| KEGG |
Oocyte meiosis pathway
mRNA surveillance pathway pathway
Oocyte meiosis pathway
mRNA surveillance pathway pathway
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| INOH |
Insulin receptor signaling pathway
GPCR Dopamine D1like receptor signaling pathway pathway
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| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | Q08DP7 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 505915 | ||||||||
| UniGene | Bt.2327 | ||||||||
| RefSeq | NM_001075232 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC123630 DAAA02063544 | ||||||||
| GenPept | AAI23631 | ||||||||
| RNA Seq Atlas | 505915 | ||||||||