Version 5.4
Mus musculus Gene: Cited2
Summary
InnateDB Gene IDBG-134872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cited2
Gene Name Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Synonyms AI835299; ER154-like; Mrg1; Msg2; p35srj
Species Mus musculus
Ensembl Gene ENSMUSG00000039910
Encoded Proteins
IDBP-134874
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164442:
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:17723228-17725673
Strand Forward strand
Band A2
Transcripts
ENSMUST00000038107 ENSMUSP00000038405
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0035035 histone acetyltransferase binding
GO:0046332 SMAD binding
GO:0050693 LBD domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001829 trophectodermal cell differentiation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0001889 liver development
GO:0001892 embryonic placenta development
GO:0001944 vasculature development
GO:0001947 heart looping
GO:0002089 lens morphogenesis in camera-type eye
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002521 leukocyte differentiation
GO:0003151 outflow tract morphogenesis
GO:0003156 regulation of organ formation
GO:0003197 endocardial cushion development
GO:0003281 ventricular septum development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007368 determination of left/right symmetry
GO:0007417 central nervous system development
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007530 sex determination
GO:0007569 cell aging
GO:0008283 cell proliferation
GO:0008584 male gonad development
GO:0009612 response to mechanical stimulus
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0021602 cranial nerve morphogenesis
GO:0022409 positive regulation of cell-cell adhesion
GO:0030325 adrenal gland development
GO:0030336 negative regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030851 granulocyte differentiation
GO:0034405 response to fluid shear stress
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035802 adrenal cortex formation
GO:0035914 skeletal muscle cell differentiation
GO:0043066 negative regulation of apoptotic process
GO:0043627 response to estrogen
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046697 decidualization
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048821 erythrocyte development
GO:0060136 embryonic process involved in female pregnancy
GO:0060349 bone morphogenesis
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060971 embryonic heart tube left/right pattern formation
GO:0061156 pulmonary artery morphogenesis
GO:0061308 cardiac neural crest cell development involved in heart development
GO:0061371 determination of heart left/right asymmetry
GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070986 left/right axis specification
GO:0071363 cellular response to growth factor stimulus
GO:1900164 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:2000020 positive regulation of male gonad development
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164442
View Gene Order
ENSBTAG00000011224
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
hif2pathway
HIF-2-alpha transcription factor network
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt O35740
TrEMBL
UniProt Splice Variant
Entrez Gene 17684
UniGene Mm.272321 Mm.470438
RefSeq NM_010828 XM_006512576
OMIM
CCDS CCDS23708
HPRD
IMGT
MGI ID MGI:1306784
MGI Symbol Cited2
EMBL AC105167 AK131664 AK133791 BC057126 CH466562 U86445 Y15163
GenPept AAC39945 AAH57126 BAE20751 BAE21844 CAA75432 CAA75433 CAA75434 CAA75435 EDL03481
RNA Seq Atlas 17684

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca